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Masafumi Takahashi Selected Research

Inflammasomes

6/2022dsDNA-induced AIM2 pyroptosis halts aberrant inflammation during rhabdomyolysis-induced acute kidney injury.
1/2022NLRP3 inflammasome is involved in testicular inflammation induced by lipopolysaccharide in mice.
1/2022Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome.
1/2022NLRP3 inflammasome as a key driver of vascular disease.
1/2022Loop Between NLRP3 Inflammasome and Reactive Oxygen Species.
1/2022Elevated S100A9 in preeclampsia induces soluble endoglin and IL-1β secretion and hypertension via the NLRP3 inflammasome.
11/2021NLRP3 Inflammasome as a Common Denominator of Atherosclerosis and Abdominal Aortic Aneurysm.
11/2021β-hydroxybutyrate suppresses NLRP3 inflammasome-mediated placental inflammation and lipopolysaccharide-induced fetal absorption.
8/2021Endothelial Dysfunction Accelerates Impairment of Mitochondrial Function in Ageing Kidneys via Inflammasome Activation.
5/2021Deletion of inflammasome adaptor protein ASC enhances functional recovery after spinal cord injury in mice.
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Masafumi Takahashi Research Topics

Disease

38Inflammation (Inflammations)
01/2022 - 03/2002
19Atherosclerosis
01/2022 - 03/2002
15Myocardial Infarction
01/2019 - 01/2002
11Fibrosis (Cirrhosis)
02/2019 - 01/2005
9Cardiovascular Diseases (Cardiovascular Disease)
11/2021 - 01/2003
8Neoplasms (Cancer)
05/2012 - 11/2003
7Vascular System Injuries
01/2022 - 04/2006
7Reperfusion Injury
01/2020 - 07/2005
6Ischemia
01/2020 - 03/2002
6Heart Failure
02/2019 - 09/2004
5Neoplasm Metastasis (Metastasis)
12/2021 - 09/2010
5Pregnancy Complications
11/2021 - 01/2015
5Pulmonary Arterial Hypertension
01/2019 - 10/2006
5Atherosclerotic Plaque (Atheroma)
08/2012 - 03/2002
5Coronary Artery Disease (Coronary Atherosclerosis)
04/2011 - 03/2002
4Aortic Aneurysm (Aneurysm, Aortic)
01/2022 - 05/2004
4Thrombosis (Thrombus)
01/2022 - 01/2019
4Hypoxia (Hypoxemia)
10/2020 - 10/2006
4Infarction (Infarctions)
04/2015 - 09/2007
4Heart Diseases (Heart Disease)
08/2014 - 09/2003
4Left Ventricular Dysfunction
01/2012 - 10/2006
3Vasculitis (Vasculitides)
01/2022 - 01/2018
3Mucocutaneous Lymph Node Syndrome (Kawasaki Disease)
01/2022 - 01/2018
3Pre-Eclampsia (Preeclampsia)
01/2022 - 11/2015
3Obesity
06/2020 - 01/2016
3Acute Lung Injury
01/2020 - 02/2015
3Liver Diseases (Liver Disease)
02/2019 - 07/2005
3Necrosis
10/2016 - 03/2006
3Carcinogenesis
01/2012 - 02/2008
3Bradycardia
01/2010 - 01/2005
3Myocarditis (Carditis)
09/2007 - 09/2005
3Hyperplasia
07/2006 - 01/2003
3Arteriosclerosis
11/2004 - 01/2003
2Rhabdomyolysis
06/2022 - 06/2015
2Hypertension (High Blood Pressure)
01/2022 - 11/2015
2Communicable Diseases (Infectious Diseases)
01/2022 - 11/2003
2Prostatic Neoplasms (Prostate Cancer)
12/2021 - 07/2019
2Abdominal Aortic Aneurysm
11/2021 - 01/2019
2Maternal Obesity
06/2020 - 01/2016
2Acute Liver Failure (Fulminant Hepatic Failure)
01/2020 - 01/2002
2Wounds and Injuries (Trauma)
02/2019 - 01/2011
2Vascular Remodeling
01/2019 - 07/2006
2Infections
01/2019 - 11/2003
2Ventricular Tachycardia
01/2019 - 04/2015
2Atrial Fibrillation
01/2016 - 01/2010
2Cardiotoxicity
01/2016 - 01/2012
2Proteinuria
11/2015 - 12/2011
2Chronic Renal Insufficiency
09/2015 - 05/2014
2Hypertrophy
11/2014 - 10/2006
2Reinjuries
12/2013 - 02/2011

Drug/Important Bio-Agent (IBA)

47InflammasomesIBA
06/2022 - 06/2008
19Proteins (Proteins, Gene)FDA Link
11/2021 - 07/2003
13CytokinesIBA
01/2022 - 04/2002
10InterleukinsIBA
11/2021 - 10/2006
8NucleotidesIBA
01/2022 - 01/2015
7LipidsIBA
06/2020 - 03/2002
6Mycophenolic Acid (Cellcept)FDA LinkGeneric
10/2006 - 07/2003
5Leucine (L-Leucine)FDA Link
01/2022 - 01/2018
5Interleukin-6 (Interleukin 6)IBA
01/2018 - 03/2002
4Reactive Oxygen Species (Oxygen Radicals)IBA
01/2020 - 06/2008
4Interleukin-10 (Interleukin 10)IBA
01/2018 - 09/2007
4Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
06/2008 - 03/2006
4KRP-203IBA
09/2007 - 01/2005
4Macrophage Colony-Stimulating FactorIBA
09/2007 - 07/2003
4Transforming Growth Factor beta1 (TGF beta 1)IBA
07/2006 - 06/2004
3DNA (Deoxyribonucleic Acid)IBA
06/2022 - 11/2003
3LipopolysaccharidesIBA
01/2022 - 10/2020
3canakinumabFDA Link
01/2022 - 01/2019
3Caspase 1 (ICE Protease)IBA
11/2021 - 01/2020
3Palmitic Acid (Hexadecanoic Acid)IBA
06/2020 - 01/2016
3CholesterolIBA
11/2018 - 01/2004
3Apolipoproteins E (ApoE)IBA
01/2015 - 03/2012
3Green Fluorescent ProteinsIBA
04/2009 - 12/2005
3OsteopontinIBA
02/2009 - 06/2004
3MonocrotalineIBA
09/2007 - 07/2007
3Endothelin-1 (Endothelin 1)IBA
07/2006 - 01/2005
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2004 - 03/2002
2Interleukin-18 (Interleukin 18)IBA
11/2021 - 06/2008
2Glucose (Dextrose)FDA LinkGeneric
10/2020 - 11/2016
2Nonesterified Fatty Acids (NEFA)IBA
06/2020 - 01/2020
2Pharmaceutical PreparationsIBA
01/2020 - 09/2007
2IronIBA
01/2020 - 01/2020
2Fatty Acids (Saturated Fatty Acids)IBA
01/2018 - 01/2016
2Messenger RNA (mRNA)IBA
01/2016 - 09/2005
2Angiotensin IIIBA
11/2015 - 01/2015
2Coloring Agents (Dyes)IBA
04/2015 - 01/2012
2Amlodipine (Norvasc)FDA LinkGeneric
11/2014 - 07/2007
2ApolipoproteinsIBA
08/2012 - 03/2012
2EthionineIBA
04/2012 - 02/2008
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
04/2012 - 01/2011
2Choline (Choline Chloride)IBA
04/2012 - 02/2008
2VLDL receptorIBA
04/2011 - 02/2006
2Lipoproteins (Lipoprotein)IBA
04/2011 - 01/2004

Therapy/Procedure

15Therapeutics
11/2021 - 09/2003
5Liver Transplantation
01/2020 - 01/2002
5Transplantation
04/2015 - 01/2003
3Drug Therapy (Chemotherapy)
01/2020 - 04/2009
3Bone Marrow Transplantation (Transplantation, Bone Marrow)
01/2016 - 11/2008
2Gamma Cameras (Gamma Camera)
12/2021 - 07/2019
2Rewarming
10/2016 - 01/2016